Preheat your oven to 350°F (180°C). Line a baking sheet with aluminum foil or parchment paper. In a large bowl, combine the chicken thighs with olive oil, salt, garlic powder, onion powder, paprika, cayenne, and black pepper.
Bake in the preheated oven for 15-20 minutes, or until the chicken reaches an internal temperature of 165°F (74°C) when checked with a meat thermometer. If desired place under the broiler for a couple of minutes.
Remove the chicken from the oven and let it rest for about 5 minutes. This helps the juices redistribute and keeps your chicken moist. Serve the baked chicken thighs with your choice of sides, like mashed potatoes, rice, pasta, salad, or steamed veggies.